Condition Guide

Autoimmune Support: Calming the Immune System Naturally

Autoimmune diseases occur when your immune system attacks your own tissues. While conventional medicine focuses on suppressing the immune response, functional medicine asks why it's activated in the first place.

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Understanding Autoimmunity

Your immune system is designed to attack foreign invaders while leaving your own tissues alone. In autoimmune disease, this recognition fails — the immune system mistakes self as enemy.

Gut-Immune Link

70-80% of your immune system lives in your gut. Gut dysfunction is central to autoimmunity.

Inflammation Driver

Autoimmunity involves chronic inflammation that damages tissues and causes symptoms.

Food Triggers

Certain foods can trigger or exacerbate autoimmune flares through molecular mimicry or inflammation.

Stress Connection

Chronic stress dysregulates immune function and often triggers autoimmune flares.

Common Autoimmune Conditions

Hashimoto's thyroiditis
Rheumatoid arthritis
Lupus
Multiple sclerosis
Celiac disease
Type 1 diabetes
Psoriasis
Inflammatory bowel disease
Sjögren's syndrome

The Triad of Autoimmunity

Researcher Alessio Fasano's work identified three factors that must be present for autoimmune disease to develop:

1

Genetic Predisposition

You have genes that increase susceptibility. However, genes alone don't cause autoimmunity — they simply load the gun. Environment pulls the trigger.

2

Environmental Trigger

Something activates those genes — infections, toxins, food proteins, stress. Identifying and removing triggers is key to calming autoimmunity.

3

Intestinal Permeability

Leaky gut allows triggers access to the immune system. This is the factor you have the most control over.

Heal the gut → potentially put autoimmunity into remission

Important Note

Autoimmune diseases are serious medical conditions. Work with qualified practitioners. Don't stop prescribed medications without medical guidance. Holistic approaches work alongside, not instead of, appropriate medical care.

Common Triggers

Leaky Gut

Intestinal permeability may be a prerequisite for autoimmune development

Gluten

Triggers zonulin release, opening tight junctions in the gut

Molecular Mimicry

Food proteins or pathogens that resemble body tissues

Chronic Infections

EBV, herpes viruses, and bacteria linked to autoimmune onset

Toxins

Heavy metals, mold, chemicals trigger immune dysregulation

Chronic Stress

Dysregulates immune function and triggers flares

The Functional Medicine Approach

1

Heal the Gut

Address leaky gut, dysbiosis, and infections. The gut is ground zero for autoimmunity — healing it is often the single most impactful intervention.

2

Identify Food Triggers

Elimination diet (often AIP — autoimmune protocol) to find personal triggers. What triggers one person may not affect another.

3

Remove Gluten

Gluten drives intestinal permeability and is problematic for most with autoimmunity — not just those with celiac disease.

4

Reduce Inflammation

Anti-inflammatory diet and lifestyle to calm the immune response. Inflammation perpetuates the autoimmune cycle.

5

Manage Stress

Stress reduction is critical. The nervous system directly influences immune function. Many flares are triggered by stressful events.

6

Address Infections

Identify and address chronic infections that may be driving immune activation. EBV reactivation is particularly common in autoimmune conditions.

The Autoimmune Protocol (AIP)

AIP is an elimination diet designed for autoimmune conditions. It removes foods most likely to trigger immune reactions, then systematically reintroduces them.

Foods Eliminated

Grains (all, including gluten-free)
Legumes
Dairy
Eggs
Nightshades (tomatoes, peppers, potatoes)
Nuts and seeds
Alcohol
Refined sugars
Food additives

Foods Emphasized

Quality meats and organ meats
Fish and seafood
Vegetables (except nightshades)
Fermented foods
Bone broth
Healthy fats
Herbs and non-seed spices

Supportive Supplements

Vitamin D: Critical immune modulator; deficiency is common in autoimmunity
Omega-3s: Anti-inflammatory; support immune balance
Glutathione: Master antioxidant; supports detox and immune function
Probiotics: Support gut health and immune regulation
Curcumin: Potent anti-inflammatory
Vitamin A: Supports gut barrier and immune tolerance

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